Journal: Blood Cancer Journal

Article Title: Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

doi: 10.1038/s41408-022-00773-8

Figure Lengend Snippet: Summary of major studies associating L-CH with lymphoid malignancy.

Article Snippet: Terao et al. (2020) , Detection of mCAs in blood from one or more Infinium Human SNP Arrays , 179,417 individuals from the Biobank Japan cohort , Common mutational precursors of CLL (trisomy 12, 13q deletion, and 13q LOH) were less frequent in Japanese individuals compared to the UK Biobank cohort. Selective pressure for specific mCAs varies with genetic background, consistent with the lower rates of CLL and higher rates of T-cell leukemia in the Japanese. , [ ] .

Techniques: Genome Wide, Sequencing, Mutagenesis, Clone Assay, Biomarker Discovery, Microarray, DNA Sequencing, Clinical Proteomics